Hangover Links Nuclear RNA Signaling to cAMP Regulation via the Phosphodiesterase 4d Ortholog dunce

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• 作者：Manuela Ruppert¹ ; ⁴ ; Mirjam Franz² ; ⁴ ; Anastasios Saratsis² ; Laura Velo Escarcena¹ ; Oliver Hendrich¹ ; ⁵ ; Li Ming Gooi¹ ; ⁶ ; Isabell Schwenkert² ; Ansgar Klebes³ ; Henrike Scholz¹ ; ² ; ⁷ ; ^{henrike.scholz@uni-koeln.de}
• 关键词：hangover ; dunce ; Dunce isoforms ; PDE4d ; cellular stress ; alcohol tolerance ; Drosophila melanogaster
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：533-544
• 全文大小：3517 K
• 卷排序：18

文摘

The nuclear stress protein Hangover binds RNA. The Pde4d ortholog dunce is a target of Hangover signaling. Both mediate experience-dependent behavioral changes in the same neurons. Hangover links two cAMP-dependent mechanisms to regulate ethanol tolerance.