Diverse action of lipoteichoic acid and lipopolysaccharide on neuroinflammation, blood-brain barrier disruption, and anxiety in mice

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• 作者：Raphaela Mayerhofer^a ; Esther E. Frö ; hlich^a ; Florian Reichmann^a ; Aitak Farzi^a ; Nora Kogelnik^b ; Eleonore Frö ; hlich^c ; Wolfgang Sattler^b ; Peter Holzer^a ; ^d ; ^{peter.holzer@medunigraz.at}
• 关键词：ACTB ; beta actin ; BBB ; blood-brain barrier ; CA ; central area ; CCL2 ; chemokine (CC motif) ligand 2 ; CLDN5 ; claudin 5 ; DMSO ; dimethyl sulfoxide ; EU ; endotoxin unit ; GAPDH ; glycerinaldehyde-3-phosphate-Dehydrogenase ; HEK ; human embryonic kidney ; HPA ; hypothalamic-pituitary-adrenal ; hTLR ; human Toll-like receptor ; IFN ; interferon ; IL ; interleukin ; i.p. ; intraperitoneal ; LPS ; lipopolysaccharide ; LTA ; lipoteichoic acid ; NOD ; nucleotide-binding oligomerization domain ; OCLN ; occludin ; PAMP ; pathogen ass
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：174-187
• 全文大小：3118 K
• 卷排序：60

文摘

Microbial Toll-like receptor (TLR) agonists affect immune system, brain and behavior. The TLR2 agonist lipoteichoic acid (LTA) upregulates plasma and brain cytokines. LTA-induced neuroinflammation may lead to blood-brain barrier disruption. The analysis of LTA effects can be obscured by lipopolysaccharide contaminations.