Relaxin-3 is associated with metabolic syndrome and its component traits in women

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• 作者：Maivel H. Ghattas^a ; Eman T. Mehanna^b ; Noha M. Mesbah^b ; Dina M. Abo-Elmatty^b ; ^{dinawahadan@yahoo.com}
• 关键词：IGF ; insulin-like growth factor ; INSL ; insulin-like peptide ; RXFP3 ; relaxin family peptide 3 receptor ; CVD ; cardiovascular disease ; TG ; triglyceride ; HDL-C ; high density lipoprotein cholesterol ; ASCVD ; atherosclerotic cardiovascular disease ; FBG ; fasting
• 刊名：Clinical Biochemistry
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：46
• 期：1-2
• 页码：45-48
• 全文大小：185 K

文摘

4 class=""h4"">Objectives4>Relaxin-3 was found to play a role in appetite regulation, increasing food intake and body weight. The current study aimed to investigate the relation of relaxin-3 to metabolic syndrome and its component traits in women.4 class=""h4"">Design and methods4>

The study was conducted on 300 female subjects, 150 healthy control and 150 metabolic syndrome patients. The component traits of metabolic syndrome were determined for all participants.4 class=""h4"">Results4>

Serum relaxin-3 level was significantly higher in the metabolic syndrome patients than in the healthy control group. It was also significantly correlated with all the component traits of metabolic syndrome.4 class=""h4"">Conclusion4>

The results suggest that metabolic syndrome is associated with increased serum relaxin-3 levels in women. Relaxin-3 might be considered as a potential biomarker of metabolic syndrome.