Heart rate variability in major depressive disorder and after antidepressant treatment with agomelatine and paroxetine: Findings from the Taiwan Study of Depression and Anxiety (TAISDA)

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Heart rate variability in major depressive disorder and after antidepressant treatment with agomelatine and paroxetine: Findings from the Taiwan Study of Depression and Anxiety (TAISDA)

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作者：Ta-Chuan Yeh^a ; Lien-Cheng Kao^b ; Nian-Sheng Tzeng^a ; ^c ; Terry B.J. Kuo^d ; San-Yuan Huang^a ; Chuan-Chia Chang^a ; ; Hsin-An Chang^a ; ^{chang.ha@mail.ndmctsgh.edu.tw" class="auth_mail" title="E-mail the corresponding author}
关键词：ANOVA ; Analysis of variance ; BMI ; Body mass index ; BDI ; Beck Depression Inventory ; BAI ; Beck Anxiety Inventory ; CVD ; Cardiovascular disease ; DBP ; Diastolic blood pressure ; HRV ; Heart rate variability ; HAM-D ; Hamilton Depression Rating Scale ; HAM-A ; Hamilton Anxiety Rating Scale ; HF ; High-frequency power ; LF ; Low-frequency power ; MDD ; Major depressive disorder ; MANOVA ; Multivariate analysis of variance ; MT1 ; MT1 subtype of mela ; toninergic receptors ; MT2 ; MT2 subtype of mela ; toninergic rec
刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
出版年：2016
出版时间：4 January 2016
年：2016
卷：64
期：Complete
页码：60-67
全文大小：640 K

文摘

•: Previous studies have observed reduced heart rate variability (HRV) in depression.
•: The effects of major depression and antidepressants on HRV were measured.
•: Unmedicated patients with major depression displayed lower HRV than controls.
•: Depression severity independently contributed to decreased HRV and vagal tone.
•: Compared with paroxetine, agomelatine had a more vagotonic effect.