Vorinostat in refractory soft tissue sarcomas - Results of a multi-centre phase II trial of the German Soft Tissue Sarcoma and Bone Tumour Working Group (AIO)

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Vorinostat in refractory soft tissue sarcomas - Results of a multi-centre phase II trial of the German Soft Tissue Sarcoma and Bone Tumour Working Group (AIO)

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作者：Thomas Schmitt^a ; ¹ ; ^{th_schmitt@gmx.de" class="auth_mail" title="E-mail the corresponding author} ; Regine Mayer-Steinacker^b ; ^{regine.mayer-steinacker@uniklinik-ulm.de" class="auth_mail" title="E-mail the corresponding author} ; Frank Mayer^c ; ^{frank.mayer@med.uni-tuebingen.de" class="auth_mail" title="E-mail the corresponding author} ; Viktor Grü ; nwald^d ; ^{Gruenwald.Viktor@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author} ; Jochen Schü ; tte^e ; ² ; ^{mail@onkologie-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author} ; Jö ; rg T. Hartmann^f ; ³ ; ^{medklinik2@franziskus.de" class="auth_mail" title="E-mail the corresponding author} ; Bernd Kasper^g ; ^{Bernd.Kasper@umm.de" class="auth_mail" title="E-mail the corresponding author} ; Johannes Hü ; sing^h ; ^{johannes.huesing@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Jacek Hajda^h ; ^{jacek.hajda@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Gregor Ottawa^h ; ^{gregor.ottawa@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Gunhild Mechtersheimerⁱ ; ^{gunhild.mechtersheimer@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Gerd Mikus^j ; ^{gerd.mikus@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Jü ; rgen Burhenne^j ; ^{juergen.burhenne@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Lorenz Lehmann^k ; ^{lorenz.lehmann@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Christoph E. Heilig^a ; ^{christoph.heilig@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Anthony D. Ho^a ; ^{anthony.ho@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Gerlinde Egerer^a ; ^{gerlinde.egerer@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author}
关键词：Soft Tissue Sarcoma ; Metastatic ; Locally advanced ; Vorinostat ; Histone deacetylase-inhibition
刊名：European Journal of Cancer
出版年：2016
出版时间：September 2016
年：2016
卷：64
期：Complete
页码：74-82
全文大小：620 K

文摘

•: First multi-centre trial on vorinostat in Soft Tissue Sarcoma.
•: Objective response to treatment was low.
•: A subgroup of patients experienced long-lasting disease stabilisation.