Astroglioma conditioned medium increases synaptic elimination and correlates with major histocompatibility complex of class I (MHC I) upregulation in PC12Cells

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Astroglioma conditioned medium increases synaptic elimination and correlates with major histocompatibility complex of class I (MHC I) upregulation in PC12Cells

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作者：Rodrigo Fabrizzio Iná ; cio^a ; Renata Gacielle Zanon^b ; Mateus Vidigal de Castro^a ; Henrique Marques de Souza^c ; Marcio Chaim Bajgelman^d ; Liana Verinaud^a ; Alexandre Leite Rodrigues de Oliveira^a ; ^{alroliv@unicamp.br" class="auth_mail" title="E-mail the corresponding author}
关键词：Glioma ; Astrocyte ; MHC I ; PC12 ; Synapse ; Plasticity
刊名：Neuroscience Letters
出版年：2016
出版时间：10 November 2016
年：2016
卷：634
期：Complete
页码：160-167
全文大小：2201 K

文摘

•: PC12 cells may be considered as an alternative model for studying MHC I regulation and synaptic plasticity.
•: Synapse formation in PC12 cells is affected by MHC I upregulation.
•: Glioma derived soluble factors reduce synapse formation in PC12 cells.

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