Human cytomegalovirus gH/gL/UL128/UL130/UL131A complex elicits potently neutralizing antibodies in mice

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Human cytomegalovirus gH/gL/UL128/UL130/UL131A complex elicits potently neutralizing antibodies in mice

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作者：Yingxia Wen ; James Monroe ; Christine Linton ; Jacob Archer ; Clayton W. Beard ; Susan W. Barnett ; Giuseppe Palladino ; Peter W. Mason ; ² ; ^{peter.mason@novartis.com" class="auth_mail} ; ^{pwmason@utmb.edu" class="auth_mail} ; Andrea Carfi ; ^{andrea.carfi@novartis.com" class="auth_mail} ; Anders E. Lilja¹
关键词：Cytomegalovirus ; Pentameric complex ; Vaccine ; Neutralizing antibodies
刊名：Vaccine
出版年：24 June 2014
年：2014
卷：32
期：30
页码：3796-3804
全文大小：2320 K

文摘

•: Viral replicon particles (VRPs) encoding gH/gL/UL128/UL130/UL131A produce a pentameric protein complex.
•: Pentameric protein complex was purified from cells transfected with plasmid DNAs encoding the single components.
•: Sera from mice immunized with pentameric VRPs or the pentameric complex potently neutralize HCMV.
•: Neutralizing titers elicited by the pentameric complex were superior to those elicited by the gH/gL complex.

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