Safety and immunogenicity of a single dose of a quadrivalent meningococcal conjugate vaccine (MenACYW-D): a multicenter, blind-observer, randomized, phase III clinical trial in the Republic of Korea

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Safety and immunogenicity of a single dose of a quadrivalent meningococcal conjugate vaccine (MenACYW-D): a multicenter, blind-observer, randomized, phase III clinical trial in the Republic of Korea

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作者：Dong Soo Kim^a ; Min Ja Kim^b ; ^{macropha@korea.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Sung-Ho Cha^c ; Hwang Min Kim^d ; Jong-Hyun Kim^e ; Kwang Nam Kim^f ; Jin-Soo Lee^g ; Jun Yong Choi^h ; Valé ; rie Bosch Castellsⁱ ; Hee Soo Kim^j ; Joon Bang^j ; Philipp Osterⁱ
关键词：Meningococcal vaccine ; MenACYW&ndash ; D ; Immunogenicity ; Safety ; Republic of Korea
刊名：International Journal of Infectious Diseases
出版年：2016
出版时间：April 2016
年：2016
卷：45
期：Complete
页码：59-64
全文大小：404 K

文摘

•: A multicenter, blind-observer, randomized, phase III clinical trial was conducted.
•: A single dose of a meningococcal polysaccharide diphtheria toxoid conjugate vaccine (MenACYW–D) was evaluated in Korean participants aged 11–55 years.
•: MenACYW–D elicited robust immune responses with broad serogroup protection.
•: MenACYW–D showed a good safety profile with few solicited reactions.