Abnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine

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• 作者：Xin Dong^a ; ¹ ; Xinying Guan^a ; ¹ ; Keyan Chen^a ; Shanquan Jin^a ; Chengyun Wang^b ; Lanyun Yan^a ; Zhaochun Shi^a ; Xue Zhang^a ; Ling Chen^c ; Qi Wan^a ; ^{qi_wan@126.com}
• 关键词：ROS ; reactive oxygen species ; TG ; trigeminal ganglion ; Drp1 ; Dynamin related protein 1 ; Mfn1 ; Mitofusin1 ; mtDNA ; mitochondrial DNA ; PGC-1a ; peroxisome proliferator-activated receptor-gamma coactivator-1a ; NRF1 ; nuclear respiratory factor 1 ; NRF2 ; nuclear respiratory factor 2 ; TFAM ; mitochondrial transcription factor A ; IS ; inflammatory soup
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：636
• 期：Complete
• 页码：127-133
• 全文大小：2853 K
• 卷排序：636

文摘

Defective mitochondrial morphology was detected in TG neurons in a rat model of migraine. Mitochondrial dynamics was shifted towards fission in TG neurons in a rat model of migraine. Mitochondrial biogenesis was suppressed in TG neurons in a rat model of migraine.