The antioxidant transcription factor Nrf2 contributes to the protective effect of mild thermotolerance (40 </ce:hsp>°C) against heat shock-induced apoptosis

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The antioxidant transcription factor Nrf2 contributes to the protective effect of mild thermotolerance (40 °C) against heat shock-induced apoptosis

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作者：Audrey Glory ; Diana A. Averill-Bates ; ^{averill.diana@uqam.ca" class="auth_mail" title="E-mail the corresponding author}
关键词：ARE ; Antioxidant response element ; ATF-3 ; Activating transcription factor-3 ; BSA ; Bovine serum albumin ; DAF ; Diaminofluorescein ; DHE ; Dihydroethidium ; D-MEM ; Dulbecco's modification of Eagle's medium ; DTT ; Dithiothreitol ; EDTA ; Ethylene diamine tetraacetic acid ; EGTA ; Ethylene glycol tetraacetic acid ; ER ; Endoplasmic reticulum ; FITC ; Fluorescein isothiocyanate ; GCL ; Glutamate cysteine ligase ; GPx1 ; Glutathione peroxidase 1 ; GSH ; reduced glutathione ; GSR ; Glutathione S-reductase ; GST ; Glutathione
刊名：Free Radical Biology and Medicine
出版年：2016
出版时间：October 2016
年：2016
卷：99
期：Complete
页码：485-497
全文大小：5433 K

文摘

•: Thermotolerance (40 °C) increases cellular levels of pro-oxidants after 30–60 min.
•: Increased pro-oxidant generation leads to activation of the Nrf2 antioxidant pathway.
•: Nrf2 activation is diminished by inhibition of p53, indicating a positive interaction.
•: Nrf2 activation increases the protection of thermotolerance (40 °C) against apoptosis.

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