Rheb1-mTORC1 maintains macrophage differentiation and phagocytosis in mice

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Rheb1-mTORC1 maintains macrophage differentiation and phagocytosis in mice

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作者：Xiaomin Wang^a ; ¹ ; Minghao Li^a ; ¹ ; Yanan Gao^a ; ¹ ; Juan Gao^a ; Wanzhu Yang^a ; Haoyue Liang^a ; Qing Ji^a ; Yanxin Li^a ; Hanzhi Liu^a ; Jian Huang^b ; Tao Cheng^a ; Weiping Yuan^a ;
关键词：WBMCs ; whole bone marrow cells ; BM ; bone marrow ; PB ; peripheral blood ; FL ; fetal liver ; HSC ; hematopoietic stem cell ; GMP ; myeloid progenitor ; PC ; peritoneal cavity ; TG ; thioglycollate ; 3BDO ; 3-benzyl-5-((2-nitrophenoxy)methyl)&ndash ; dihydrofuran-2(3H)-one
刊名：Experimental Cell Research
出版年：2016
出版时间：10 June 2016
年：2016
卷：344
期：2
页码：219-228
全文大小：3506 K

文摘

•: Rheb1 deletion impaired myeloid development in fetal liver and adult bone marrow.
•: Rheb1 deletion inhibited the monocyte-to-macrophage differentiation process.
•: Rheb1 deletion reduced phagocytosis of macrophages by decreasing mTORC1 activity.

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