Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins

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Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins

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作者：Vahan B. Indjeian¹ ; ² ; ⁴ ; Garrett A. Kingman² ; Felicity C. Jones² ; ⁵ ; Catherine A. Guenther¹ ; ² ; Jane Grimwood³ ; Jeremy Schmutz³ ; Richard M. Myers³ ; David M. Kingsley¹ ; ² ; ^{kingsley@stanford.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell
出版年：2016
出版时间：14 January 2016
年：2016
卷：164
期：1-2
页码：45-56
全文大小：1881 K

文摘

•: Altered armor-plate size in sticklebacks maps to a cis-regulatory change in GDF6 gene
•: Increased GDF6 expression phenocopies armor evolution in transgenic fish
•: Humans have lost a conserved regulatory element controlling GDF6 expression
•: Mouse phenotypes suggest that deletion is related to digit shortening in human feet

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