Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic

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• 作者：Sid E. O'Bryant^a ; ^{sid.obryant@unthsc.edu} ; Michelle M. Mielke^b ; ^c ; Robert A. Rissman^d ; Simone Lista^e ; ^f ; Hugo Vanderstichele^g ; Henrik Zetterberg^h ; ⁱ ; Piotr Lewczuk^j ; ^k ; Holly Posner^l ; James Hall^a ; Leigh Johnson^a ; Yiu-Lian Fong^m ; Johan Luthmanⁿ ; Andreas Jeromin^o ; Richard Batrla-Utermann^p ; Alcibiades Villarreal^q ; Gabrielle Britton^q ; Peter J. Snyder^r ; Kim Henriksen^s ; Paula Grammas^t ; Veer Gupta^u ; Ralph Martins^u ; Harald Hampel^e ; ^f ; the Biofluid Based Biomarker Professional Interest Area
• 关键词：Alzheimer's disease ; Biomarker ; Blood ; Diagnosis ; Cerebrospinal fluid ; Imaging ; Diagnosis ; Context of use
• 刊名：Alzheimer's & Dementia
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：13
• 期：1
• 页码：45-58
• 全文大小：1032 K
• 卷排序：13

文摘

The last decade has seen a substantial increase in research focused on the identification of blood-based biomarkers that have utility in Alzheimer's disease (AD). Blood-based biomarkers have significant advantages of being time- and cost-efficient as well as reduced invasiveness and increased patient acceptance. Despite these advantages and increased research efforts, the field has been hampered by lack of reproducibility and an unclear path for moving basic discovery toward clinical utilization. Here we reviewed the recent literature on blood-based biomarkers in AD to provide a current state of the art. In addition, a collaborative model is proposed that leverages academic and industry strengths to facilitate the field in moving past discovery only work and toward clinical use. Key resources are provided. This new public-private partnership model is intended to circumvent the traditional handoff model and provide a clear and useful paradigm for the advancement of biomarker science in AD and other neurodegenerative diseases.