Rictor is required for optimal bone accrual in response to anti-sclerostin therapy in the mouse

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Rictor is required for optimal bone accrual in response to anti-sclerostin therapy in the mouse

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作者：Weiwei Sun^a ; ^d ; Yu Shi^a ; Wen-Chih Lee^a ; Seung-Yon Lee^a ; Fanxin Long^a ; ^b ; ^c ; ^{flong@wustl.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Rictor ; mTORC2 ; Wnt ; Sost ; Bone ; Osteoblast ; Osteoclast
刊名：Bone
出版年：2016
出版时间：April 2016
年：2016
卷：85
期：Complete
页码：1-8
全文大小：1320 K

文摘

•: Rictor-deficient mice contain normal trabecular but low cortical bone mass.
•: Rictor-deficient mice exhibit less bone resorption than normal.
•: Rictor deletion reduces Rankl expression by bone marrow stromal cells.
•: Rictor deficiency blunts bone anabolic effect of anti-sclerotin treatment.

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