Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

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Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

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作者：Stefan Christen¹ ; ² ; Doriane Lorendeau¹ ; ² ; Roberta Schmieder¹ ; ² ; Dorien Broekaert¹ ; ² ; Kristine Metzger¹ ; ² ; Koen Veys³ ; Ilaria Elia¹ ; ² ; Joerg Martin Buescher¹ ; ² ; Martin Franz Orth⁴ ; Shawn Michael Davidson⁵ ; Thomas Georg Philipp Gr&uuml ; newald⁴ ; Katrien De Bock⁶ ; Sarah-Maria Fendt¹ ; ² ; ⁷ ; ^{sarah-maria.fendt@vib-kuleuven.be" class="auth_mail" title="E-mail the corresponding author}
关键词：pyruvate carboxylase ; mitochondrial pyruvate concentration ; lung metastasis ; breast cancer ; TCA cycle anaplerosis ; microenvironment ; glycolytic metabolism ; cancer metabolism ; 13C tracer analysis ; pyruvate metabolism
刊名：Cell Reports
出版年：2016
出版时间：11 October 2016
年：2016
卷：17
期：3
页码：837-848
全文大小：3016 K

文摘

•: Lung metastases have higher PC-dependent anaplerosis than primary breast cancers
•: PC-dependent anaplerosis is a function of the in vivo microenvironment
•: Pyruvate to glutamine availability is increased in the in vivo lung microenvironment
•: Compartment-specific pyruvate distributions can be inferred from ¹³C labeling patterns

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