Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na<sup>+</sup>/K<sup>+</sup>-ATPase activity

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Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na⁺/K⁺-ATPase activity

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作者：Wilmer H. Perera Có ; rdova^a ; ^{Wilmer.Perera@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Suzana Guimarã ; es Leitã ; o^a ; Geraldino Cunha-Filho^b ; ¹ ; Roberto Alonso Bosch^c ; Isel Pascual Alonso^c ; Rogelio Pereda-Miranda^d ; Rodrigo Gervou^b ; Natá ; lia Araú ; jo Touza^b ; Luis Eduardo M. Quintas^b ; Franç ; ois Noë ; l^b
关键词：Peltophryne fustiger ; Western Giant toad ; Bufadienolides ; 1D and 2D NMR spectroscopy ; UPLC-MS/MS ; HRESIMS ; Na+/K+ ATPase
刊名：Toxicon
出版年：2016
出版时间：February 2016
年：2016
卷：110
期：Complete
页码：27-34
全文大小：1020 K

文摘

•: Ten metabolites were isolated from gland secretions of Peltophryne fustiger.
•: Arenobufagin is the major bufadienolide in this toad secretion.
•: Arenobufagin and bufalin were 100 times more potent than ψ-bufarenogin.

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