In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

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• 作者：Alejandro Ocampo¹ ; ⁶ ; Pradeep Reddy¹ ; ⁶ ; Paloma Martinez-Redondo¹ ; ⁶ ; Aida Platero-Luengo¹ ; Fumiyuki Hatanaka¹ ; Tomoaki Hishida¹ ; Mo Li¹ ; David Lam¹ ; Masakazu Kurita¹ ; ² ; Ergin Beyret¹ ; Toshikazu Araoka¹ ; ² ; Eric Vazquez-Ferrer¹ ; David Donoso¹ ; Jose Luis Roman¹ ; Jinna Xu¹ ; Concepcion Rodriguez Esteban¹ ; Gabriel Nuñ ; ez³ ; Estrella Nuñ ; ez Delicado² ; Josep M. Campistol⁴ ; Isabel Guillen⁵ ; Pedro Guillen⁵ ; Juan Carlos Izpisua Belmonte¹ ; ⁷ ; ^{belmonte@salk.edu}
• 关键词：aging ; cellular reprogramming ; lifespan ; epigenetics
• 刊名：Cell
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：167
• 期：7
• 页码：1719-1733.e12
• 全文大小：8431 K
• 卷排序：167

文摘

Partial reprogramming erases cellular markers of aging in mouse and human cells Induction of OSKM in progeria mice ameliorates signs of aging and extends lifespan In vivo reprogramming improves regeneration in 12-month-old wild-type mice