A strategy to access fused triazoloquinoline and related nucleoside analogues

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• 作者：Kapil Upadhyaya ; Arya Ajay ; Rohit Mahar ; Renu P ; ey ; Brijesh Kumar ; Sanjeev K. Shukla ; Rama Pati Tripathi
• 关键词：Cycloaddition ; Reductive cyclization ; Triazoloquinolines ; Unnatural nucleoside
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：7 October, 2013
• 年：2013
• 卷：69
• 期：40
• 页码：8547-8558
• 全文大小：959 K

文摘

Fused triazoloquinolines have been prepared starting from (E)-3-(2-nitrophenyl)-1-aryl-prop-2-en-1-ones and sugar or benzyl azides in a sequential [3+2] cycloaddition reaction, followed by one pot Pd-C assisted reduction, cyclization and aromatization. The triazolyl fused quinolines with N¹-glycosyl substituents as unnatural nucleosides have inherent potential to generate a library of compounds for bioevaluations.