PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma

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PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma

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作者：Mirjam C. Boelens¹ ; ⁵ ; Micha Nethe¹ ; ⁵ ; Sjoerd Klarenbeek¹ ; ⁵ ; Julian R. de Ruiter¹ ; Eva Schut¹ ; Nicola Bonzanni² ; Amber L. Zeeman³ ; Ellen Wientjens¹ ; Eline van der Burg¹ ; Lodewyk Wessels² ; Ren&eacute ; e van Amerongen³ ; Jos Jonkers¹ ; ⁴ ; ⁶ ; ^{j.jonkers@nki.nl" class="auth_mail" title="E-mail the corresponding author}
关键词：breast cancer ; classical invasive lobular carcinoma ; genetically engineered mouse model ; Cre-lox ; E-cadherin ; PTEN ; metastasis ; tumor microenvironment ; BEZ235
刊名：Cell Reports
出版年：2016
出版时间：23 August 2016
年：2016
卷：16
期：8
页码：2087-2101
全文大小：9404 K

文摘

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PTEN loss rescues apoptosis induced by E-cadherin loss in mouse mammary epithelium

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Combined loss of E-cadherin and PTEN is sufficient to cause mouse mammary tumors

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These mouse mammary tumors closely resemble human classical lobular carcinoma (CLC)

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Mouse CLCs induced by loss of E-cadherin and PTEN regress upon PI3K inhibition

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