An in vitro iron superoxide dismutase inhibitor decreases the parasitemia levels of Trypanosoma cruzi in BALB/c mouse model during acute phase

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An in vitro iron superoxide dismutase inhibitor decreases the parasitemia levels of Trypanosoma cruzi in BALB/c mouse model during acute phase

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作者：Francisco Olmo ; Kristí ; na Urbanová ; Maria Jose Rosales ; Ruben Martí ; n-Escolano ; Manuel Sá ; nchez-Moreno ; ^{msanchem@ugr.es" class="auth_mail" title="E-mail the corresponding author} ; Clotilde Marí ; n
关键词：Anti-chagasic ; Chemotherapy ; Trypanosomiasis ; Hydroxyphthalazine derivatives
刊名：International Journal for Parasitology: Drugs and Drug Resistance
出版年：2015
出版时间：December 2015
年：2015
卷：5
期：3
页码：110-116
全文大小：1292 K

文摘

•: Low toxicity alternative treatment against Trypanosoma cruzi in murine model.
•: The acute and chronic phases of Chagas disease.
•: In vitro evaluation against epimastigote, amastigote and trypomastigote forms.
•: Compound 2 selectively inhibits the parasite Fe-SOD enzyme.
•: Compound 2 should be followed-up in future clinical experiments.

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