Systemic inflammation, growth factors, and linear growth in the setting of infection and malnutrition

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• 作者：Mark D. DeBoer ; M.D. ; M.Sc. ; M.C.R.^a ; ^{deboer@virginia.edu} ; Rebecca J. Scharf ; M.D. ; M.P.H.^b ; Alvaro M. Leite ; M.D.^c ; Alessandra Fé ; rrer ; R.N.^c ; Alexandre Havt ; Ph.D.^c ; Relana Pinkerton ; Ph.D.^d ; Aldo A. Lima ; M.D. ; Ph.D.^c ; Richard L. Guerrant ; M.D.^d
• 关键词：Nutrition ; Diarrhea ; Growth ; Stunting ; IGF-1
• 刊名：Nutrition
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：Complete
• 页码：248-253
• 全文大小：396 K
• 卷排序：33

文摘

Among children in this developing area, symptoms of illness correlated with high-sensitivity C-reactive protein (hsCRP). hsCRP correlated positively with growth hormone (GH) and negatively with insulin-like growth factor (IGF)-1 and IGF-binding protein-3 (IGFBP-3). IGF-1 and IGFBP-3 correlated positively with height. These data are consistent with a model of inflammation-induced GH resistance.