G-CSF-induced remission in two cases of acute myeloid leukemia

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• 作者：Rudolf Benz ; Jeroen S. Goede ; Valé ; rie Parlier ; Dominique M&#xfc ; hlematter ; Martine Jotter ; Jö ; rg Fehr
• 关键词：G-CSF ; Filgrastim ; Acute myeloid leukemia (AML) ; Remission
• 刊名：Leukemia Research
• 出版年：2008
• 出版时间：July 2008
• 年：2008
• 卷：32
• 期：7
• 页码：1148-1152
• 全文大小：394 K

文摘

We report on two elderly patients with newly diagnosed acute myeloid leukemia (AML) who were treated in palliative intention because of comorbidities and intermediate or poor risk cytogenetics. Both received G-CSF to reduce the risk of infection related to neutropenia. Interestingly, one patient achieved a full hematological remission and the other a peripheral remission with dramatic reduction of the bone marrow blast count. Although a direct therapeutic effect of myeloid growth factors seems to be unusual in AML, the use of G-CSF or GM-CSF may be recommended in patients such as elderly patients who are not suited for intensive chemotherapy.