Direct Mannich reaction mediated by Fe(Cp)₂PF₆ under solvent-free conditions

详细信息    查看全文

• 作者：Rukhsana I. Kureshy ; Santosh Agrawal ; S. Saravanan ; Noor-ul H. Khan ; Arpan K. Shah ; Sayed H.R. Abdi ; Hari C. Bajaj ; E. Suresh
• 关键词：Mannich reaction ; Carbonyl compounds ; Fe(Cp)₂PF₆ ; Solvent-free synthesis ; Catalysis
• 刊名：Tetrahedron Letters
• 出版年：2010
• 出版时间：20 January 2010
• 年：2010
• 卷：51
• 期：3
• 页码：489-494
• 全文大小：828 K

文摘

Fe(Cp)₂PF₆ (5 mol  % ) efficiently catalyzed Mannich reaction of aldehydes, anilines, and ketones under solvent-free condition to give β-amino-ketones in high yield (up to 94 % ) within 30 min with anti-isomer in excess. Simple experimental conditions and product isolation procedure makes this protocol potential for the development of clean and environment-friendly strategy for the synthesis of β-amino-ketones.