Mogamulizumab Treatment Prior to Allogeneic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-versus-Host Disease

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Mogamulizumab Treatment Prior to Allogeneic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-versus-Host Disease

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作者：Takeshi Sugio¹ ; Koji Kato¹ ; ^{kojikato@intmed1.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Takatoshi Aoki² ; Takanori Ohta³ ; Noriyuki Saito⁴ ; Shuro Yoshida⁴ ; Ichiro Kawano⁴ ; Hideho Henzan⁴ ; Masanori Kadowaki⁵ ; Ken Takase⁵ ; Tsuyoshi Muta⁶ ; Kohta Miyawaki¹ ; Takuji Yamauchi¹ ; Takahiro Shima¹ ; Shuichiro Takashima¹ ; Yasuo Mori¹ ; Goichi Yoshimoto¹ ; Kenjiro Kamezaki¹ ; Katsuto Takenaka⁷ ; Hiromi Iwasaki⁷ ; Ryosuke Ogawa⁶ ; Yuju Ohno³ ; Tetsuya Eto⁴ ; Tomohiko Kamimura² ; Toshihiro Miyamoto¹ ; Koichi Akashi¹ ; ⁷
关键词：Adult T cell leukemia/lymphoma ; Mogamulizumab ; Allogeneic hematopoietic stem cell transplantation ; Graft-versus-host disease
刊名：Biology of Blood and Marrow Transplantation
出版年：2016
出版时间：September 2016
年：2016
卷：22
期：9
页码：1608-1614
全文大小：601 K

文摘

•: MOG improves disease control in patients with ATLL before allo-HSCT.
•: MOG administration before allo-HSCT increases severe acute GVHD, leading to a high incidence of transplantation-related mortality.
•: Shorter intervals from the last administration of MOG to allo-HSCT were associated with the development of severe GVHD.

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