A Systematic Single Nucleotide Polymorphism Screen to Fine-Map Alcohol Dependence Genes on Chromosome 7 Identifies Association With a Novel Susceptibility Gene ACN9

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• 作者：Danielle M. Dick ; Fazil Aliev ; Jen C. Wang ; Scott Saccone ; Anthony Hinrichs ; Sarah Bertelsen ; John Budde ; Nancy Saccone ; Tatiana Foroud ; John Nurnberger Jr. ; Xiaoling Xuei ; P.M. Conneally ; Marc Schuck
• 关键词：ACN9 ; alcohol dependence ; association ; genetics ; linkage disequilibrium
• 刊名：Biological Psychiatry
• 出版年：2008
• 出版时间：1 June 2008
• 年：2008
• 卷：63
• 期：11
• 页码：1047-1053
• 全文大小：979 K

文摘

We propose and demonstrate an experimental method for measuring the period difference in grating pair. The method uses the compensating relationship between line-density difference and the Littrow-angle difference of gratings. Far-field intensity patterns of 0th- and −1st-orders diffraction beams are monitored for alignment during the angle measurement. For a pair of 0.676 μm period gratings, the relative period difference was measured to be 798.4 × 10⁻⁶ with a standard deviation of 2.0 × 10⁻⁶.