The molecular mass of dextran used to modify magnetite nanoparticles affects insulin amyloid aggregation

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• 作者：Katarina Siposova^a ; Kristyna Pospiskova^b ; Zuzana Bednarikova^a ; ^c ; Ivo Safarik^b ; ^d ; Mirka Safarikova^d ; Martina Kubovcikova^e ; Peter Kopcansky^e ; Zuzana Gazova^a ; ^{gazova@saske.sk}
• 关键词：Amyloid aggregation ; Nanoparticles ; Magnetic fluid ; Dextran ; Insulin ; Anti-amyloid activity ; Amyloid fibrils
• 刊名：Journal of Magnetism and Magnetic Materials
• 出版年：2017
• 出版时间：1 April 2017
• 年：2017
• 卷：427
• 期：Complete
• 页码：48-53
• 全文大小：551 K
• 卷排序：427

文摘

Interference of dextran- magnetite nanoparticles with insulin amyloid aggregation. Nanoparticles inhibited insulin fibrillization and depolymerized insulin amyloid fibrils. Size of nanoparticles significantly influences their anti-amyloid activities. The most effective inhibition of insulin amyloid fibrillization was detected for the smallest nanoparticles. Contrary, DC50 values decreased with increasing size of nanoparticles.