Synthesis and biological evaluation of diversely substituted indolin-2-ones

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• 作者：Fadoua Bouchikhi ; Emilie Rossignol ; Martine Sancelme ; Bettina Aboab ; Fabrice Anizon ; Doriano Fabbro ; Michelle Prudhomme ; Pascale Moreau
• 关键词：Indolin-2-ones ; Kinases' inhibitors ; Antimicrobial agents
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2008
• 出版时间：November 2008
• 年：2008
• 卷：43
• 期：11
• 页码：2316-2322
• 全文大小：297 K

文摘

The synthesis of indolin-2-one derivatives substituted in the 3-position by an aminomethylene group bearing either an ornithine or a lysine residue is described. The inhibitory activities of these compounds toward a panel of eight kinases were examined. Furthermore, the antibacterial activities of the prepared compounds were tested against two Gram-positive bacteria Bacillus cereus and Streptomyces chartreusis, a Gram-negative bacterium Escherichia coli and a yeast Candida albicans.