Defining a novel leptin-melanocortin-kisspeptin pathway involved in the metabolic control of puberty

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Defining a novel leptin-melanocortin-kisspeptin pathway involved in the metabolic control of puberty

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作者：Maria Manfredi-Lozano¹ ; ² ; ³ ; ⁷ ; Juan Roa¹ ; ² ; ³ ; ⁴ ; ⁷ ; ^{roarivas@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Francisco Ruiz-Pino¹ ; ² ; ³ ; ⁴ ; Richard Piet⁶ ; David Garcia-Galiano¹ ; ² ; Rafael Pineda¹ ; Aurora Zamora¹ ; ² ; Silvia Leon¹ ; ² ; Miguel A. Sanchez-Garrido¹ ; ² ; ⁴ ; Antonio Romero-Ruiz¹ ; ² ; Carlos Dieguez⁵ ; Maria Jesus Vazquez¹ ; ² ; ³ ; ⁴ ; Allan E. Herbison⁶ ; Leonor Pinilla¹ ; ² ; ³ ; ⁴ ; Manuel Tena-Sempere¹ ; ² ; ³ ; ⁴ ; ^{fi1tesem@uco.es" class="auth_mail" title="E-mail the corresponding author}
关键词：α-MSH ; Kisspeptin ; Leptin ; Metabolism ; DREADDs ; Puberty
刊名：Molecular Metabolism
出版年：2016
出版时间：October 2016
年：2016
卷：5
期：10
页码：844-857
全文大小：1972 K

文摘

•: Puberty is highly sensitive to metabolic modulation and disturbed by child obesity.
•: Altered puberty is linked to adverse metabolic health outcomes via unclear mechanisms.
•: The POMC product, α-MSH, transmit leptin-mediated metabolic regulation of puberty.
•: A novel α-MSH→kisspeptin→GnRH signaling pathway is involved in the control of puberty
•: This pathway is important for the metabolic (and pharmacologic) control of puberty.

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