Analysis of a Genetic Polymorphism in the Costimulatory Molecule TNFSF4 with Hematopoietic Stem Cell Transplant Outcomes

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Analysis of a Genetic Polymorphism in the Costimulatory Molecule TNFSF4 with Hematopoietic Stem Cell Transplant Outcomes

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作者：Peter T. Jindra¹ ; Susan E. Conway¹ ; Stacy M. Ricklefs² ; Stephen F. Porcella² ; Sarah L. Anzick² ; Mike Haagenson³ ; Tao Wang⁴ ; Stephen Spellman³ ; Edgar Milford¹ ; Peter Kraft⁵ ; David H. McDermott⁶ ; Reza Abdi¹ ; ^{rabdi@rics.bwh.harvard.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Gene polymorphism ; Costimulation ; Hematopoietic stem cell transplantation ; Outcomes ; Infection ; GVHD
刊名：Biology of Blood and Marrow Transplantation
出版年：2016
出版时间：January 2016
年：2016
卷：22
期：1
页码：27-36
全文大小：1254 K

文摘

•: Analysis of SNPs in costimulatory molecules effect HSCT outcomes.
•: A total of 2345 donor–recipient pairs from two cohorts were included in this study.
•: Potential improved patient outcomes with TNFSF4 rs10912564CC genotyped donors.
•: The C variant of SNP rs10912564 creates a binding site for Myb compared with T.

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