Resveratrol inhibits plasma membrane Ca<sup>2+</sup>-ATPase inducing an increase in cytoplasmic calcium

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Resveratrol inhibits plasma membrane Ca²⁺-ATPase inducing an increase in cytoplasmic calcium

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作者：Joshua Allen Peterson ; Richard Vernon Oblad ; Jeffrey Chad Mecham ; Jason Donald Kenealey ; ^{jason_kenealey@byu.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：RES ; resveratrol ; [Ca2+]i ; cytosolic calcium concentration ; PMCA ; plasma membrane Ca2+-ATPase ; EGCG ; epigallocatechin gallate ; SERCA ; sarcoendoplasmic reticular Ca2+-ATPase ; Fura-2 ; Fura-2-Acetoxymethyl ester ; TG ; thapsigargin ; ROI ; region of interest ; HBSS ; Ca2+- and Mg2+-free Hank's Balanced Salt Solution ; FBS ; fetal bovine serum ; PBS ; phosphate-buffered saline ; BAPTA ; BAPTA-Acetoxymethyl ester ; DMSO ; dimethyl sulfoxide ; DMEM ; Dulbecco's modified Eagle medium ; ER ; endoplasmic reticulum
刊名：Biochemistry and Biophysics Reports
出版年：2016
出版时间：September 2016
年：2016
卷：7
期：Complete
页码：253-258
全文大小：1004 K

文摘

•: Resveratrol induces a rise in [Ca²⁺]_i via plasma membrane Ca²⁺-ATPase inhibition.
•: FURA-2 is compatible with resveratrol in measuring [Ca²⁺]_i.
•: PMCA inhibition is novel to resveratrol among naturally occurring polyphenols.

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