Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation

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• 作者：Anja Pi&scaron ; larup>aup>up> ; up>up>anja.pislar@ffa.uni-lj.siup> ; Biljana Božićup>bup> ; Nace Zidarup>cup> ; Janko Kosup>aup>up> ; up>up>dup>
• 关键词：Cathepsin X ; γ-Enolase ; Microglia ; Neuroinflammation ; Neuroprotection
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：114
• 期：Complete
• 页码：88-100
• 全文大小：2612 K
• 卷排序：114

文摘

Microglia activation induces cathepsin X expression and its activity. Cathepsin X inhibition suppresses microglia activation. Cathepsin X mediates microglia activation-mediated neurodegeneration. Cathepsin X inhibition exerts neuroprotection.