ALK-FISH borderline cases in non-small cell lung cancer: Implications for diagnostics and clinical decision making

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ALK-FISH borderline cases in non-small cell lung cancer: Implications for diagnostics and clinical decision making

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作者：Maximilian von Laffert^a ; Albrecht Stenzinger^b ; Michael Hummel^a ; Wilko Weichert^b ; Dido Lenze^a ; Arne Warth^b ; Roland Penzel^b ; Hermann Herbst^c ; Udo Kellner^d ; Philipp Jurmeister^a ; Peter Schirmacher^b ; Manfred Dietel^a ; Frederick Klauschen^a ; ^{frederick.klauschen@charite.de" class="auth_mail" title="E-mail the corresponding author}
关键词：ADC ; adenocarcinoma ; ADSC ; adenosquamous carcinoma ; ALK ; anaplastic lymphoma kinase ; BL ; borderline ; CNG ; copy number gain ; EMA ; European Medicines Agency ; FDA ; Food and Drug Administration ; FISH ; fluorescence in-situ hybridization ; FS ; fused signals ; FN ; false negative ; FP ; false positive ; HER2 ; human epidermal growth factor receptor ; IHC ; immunohistochemistry ; LCC ; large cell carcinoma ; NOS ; not otherwise specified ; NSCLC ; non-small cell lung cancer ; SCC ; squamous cell carcinoma ; SS ; split sig
刊名：Lung Cancer
出版年：2015
出版时间：December 2015
年：2015
卷：90
期：3
页码：465-471
全文大小：1523 K

文摘

•: TMAs of 753 NSCLCs were tested for ALK-alterations by FISH and IHC.
•: 5.7% showed alterations between 10% and 20% (ALK-FISH borderline group).
•: Partly these samples showed conflicting IHC results.
•: Based on a sharp cut-off point (15%), ALK-FISH misclassifications occur frequently.
•: Based on a borderline interval, ALK-FISH misclassifications can be reduced clearly.

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