Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

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Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

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作者：Gaspar J. Kitange¹ ; ^{kitange.gaspar@mayo.edu" class="auth_mail" title="E-mail the corresponding author} ; Ann C. Mladek¹ ; Mark A. Schroeder¹ ; Jenny C. Pokorny¹ ; Brett L. Carlson¹ ; Yuji Zhang² ; ⁴ ; Asha A. Nair² ; Jeong-Heon Lee³ ; Huihuang Yan² ; Paul A. Decker² ; Zhiguo Zhang³ ; Jann N. Sarkaria¹
关键词：RBBP4 ; temozolomide ; resistance ; MGMT ; glioblastoma
刊名：Cell Reports
出版年：2016
出版时间：22 March 2016
年：2016
卷：14
期：11
页码：2587-2598
全文大小：3000 K

文摘

•: RBBP4 disruption sensitizes GBM cells to temozolomide
•: RBBP4 controls temozolomide sensitivity by regulating multiple DNA repair proteins
•: RBBP4 regulates the expression of MGMT, RAD51, FIGNL1, and EYA1
•: RBBP4 interacts with CBP/p300 to enhance chromatin-mediated gene expression

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