Regulation of inflammatory biomarkers by intravenous methylprednisolone in pediatric ARDS patients: Results from a double-blind, placebo-controlled randomized pilot trial

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Regulation of inflammatory biomarkers by intravenous methylprednisolone in pediatric ARDS patients: Results from a double-blind, placebo-controlled randomized pilot trial

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作者：Andreas Schwingshackl^a ; ^{aschwingshackl@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Dai Kimura^b ; Cynthia R. Rovnaghi^c ; Jordy S. Saravia^b ; Stephania A. Cormier^b ; Bin Teng^d ; Alina N. West^b ; Umberto G. Meduri^e ; Kanwaljeet J.S. Anand^f
关键词：ARDS ; Acute Respiratory Distress Syndrome ; GC ; glucocorticoid ; EGF ; epidermal growth factor ; FGF-2 ; fibroblast growth factor-2 ; Flt3L ; fms-like tyrosine kinase 3 ligand ; G-CSF ; granulocyte-colony stimulating factor ; GM-CSF ; granulocyte monocyte-colony stimulating factor ; GRO ; growth related cytokine ; INF-α2 ; interferon-α2 ; IFN-γ ; interferon-γ ; IL-1α ; interleukin1α ; IL-1β ; interleukin-1β ; IL-1ra ; interleukin-1 receptor antagonist ; IL-2 ; interleukin-2 ; IL-3 ; interleukin-3 ; IL-4 ; interleukin-4 ; IL-
刊名：Cytokine
出版年：2016
出版时间：January 2016
年：2016
卷：77
期：Complete
页码：63-71
全文大小：593 K

文摘

•: Low-dose steroid therapy in PARDS is feasible and may improve ventilation and oxygenation.
•: The molecular mechanisms underlying potential changes in these outcomes remained unclear.
•: This study examines the effects of IV methylprednisolone on plasma biomarkers of PARDS.
•: We simultaneously measured cytokines, cell counts and coagulation parameters in PARDS.
•: We report statistical models useful for future RCTs to predict ARDS severity and outcomes.