Disease progression and oxidative stress are associated with higher serum ferritin levels in patients with multiple sclerosis

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• 作者：Katerine Panichi Zanin Ferreira^a ; Sayonara R Oliveira^b ; Ana Paula Kallaur^a ; Damacio R Kaimen-Maciel^c ; Marcell Alysson B Lozovoy^b ; Elaine Regina Delicato de Almeida^b ; Helena Kaminami Morimoto^b ; Leda Mezzaroba^b ; Isaias Dichi^c ; Edna Maria Vissoci Reiche^b ; André ; a Name Colado Simã ; o^b ; ^{deianame@yahoo.com.br}
• 关键词：Ferritin ; Multiple sclerosis ; Oxidative stress ; Disease progression ; Hyperferritinemia
• 刊名：Journal of the Neurological Sciences
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：373
• 期：Complete
• 页码：236-241
• 全文大小：428 K
• 卷排序：373

文摘

Ferritin and iron homeostasis have been implicated in the pathogenesis of multiple sclerosis. Hyperferritinemia is associated with disease progression in multiple sclerosis patients Hyperferritinemia is associated with oxidative stress markers in multiple sclerosis patients. Increased oxidative stress was shown by elevated serum AOPP levels and reduced NOx and TRAP levels. The combination of serum ferritin levels and oxidative markers were responsible for around 14% in the disease progression.