The regulation of high insulin levels on ovary apoptosis in early pregnant mice

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• 作者：Chen Zhang^a ; ¹ ; Juan Wu^c ; ¹ ; Junlin He^a ; Xueqing Liu^a ; Xuemei Chen^a ; Chao Tong^b ; Yubin Ding^a ; Yanqing Geng^a ; Wenqi Chen^a ; Yingxiong Wang^a ; ^{wyx61221@aliyun.com} ; Rufei Gao^a ; ^{gao_ru_fei@163.com}
• 关键词：Insulin ; Apoptosis ; Ovary ; Hyperinsulinemia ; Decidualization
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：786-792
• 全文大小：2279 K
• 卷排序：483

文摘

We found that hormone secretion from the ovary is altered after insulin treatment. Ovary Apoptosis is reduced in early pregnancy mice with high insulin treatment. PI3K/AKT signalling pathway is involved in apoptosis inhibited by high insulin levels.