Ts8 demonstrates to be a selective modulator of Kv4.2 channels.

Ts8 induced overt nociception (licking and lifting behaviors).

Ts8 decreased the mechanical nociceptive threshold (hyperalgesia).

Ts8 prolonged hyperalgesia when intrathecal injections were performed.

This study also stresses the involvement of toxins specific to Nav channels on the Ts painful sting.