Stigmurin and TsAP-2 from Tityus stigmurus scorpion venom: Assessment of structure and therapeutic potential in experimental sepsis

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Stigmurin and TsAP-2 from Tityus stigmurus scorpion venom: Assessment of structure and therapeutic potential in experimental sepsis

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作者：Alessandra Daniele-Silva^a ; Richele J.A. Machado^a ; ^b ; Norberto K.V. Monteiro^c ; André ; ia B. Estrela^a ; Elizabeth C.G. Santos^a ; Eneas Carvalho^d ; Raimundo F. Araú ; jo Jú ; nior^e ; Raniere F. Melo-Silveira^b ; Hugo Alexandre O. Rocha^b ; Arnó ; bio A. Silva-Jú ; nior^a ; Matheus F. Fernandes-Pedrosa^a ; ^b ; ^{mpedrosa@ufrnet.br" class="auth_mail" title="E-mail the corresponding author}
关键词：Scorpion ; Structural assessment ; Antimicrobial peptides ; Antiproliferative ; Sepsis
刊名：Toxicon
出版年：2016
出版时间：October 2016
年：2016
卷：121
期：Complete
页码：10-21
全文大小：2941 K

文摘

•: Tityus stigmurus venom encode a peptide with mature amino acid sequence identical to TsAP-2 from T. serrulatus.
•: TsAP-2 changed its secondary structure depending on the polarity of the environment.
•: Stigmurin and TsAP-2 were stable to temperature and pH variation in the presence of SDS.
•: Stigmurin and TsAP-2 showed antimicrobial activity in vitro and ex vivo.
•: Stigmurin and TsAP-2 were effective to reduce microbial load and inflammation in experimental sepsis.

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