Synthesis, characterization and biological studies of some novel 3-fluorosalicylaldehyde based amine derivatives

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• 作者：M. Shanmugam ; K. Narayanan ; M. Mahalakshmi ; S. Kabilan ; V. Chidambaranathan
• 关键词：1D-NMR ; 2D-NMR spectroscopy ; Single crystal-XRD ; Ionic liquid ; Antimicrobial activity
• 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
• 出版年：2013
• 出版时间：December, 2013
• 年：2013
• 卷：116
• 期：Complete
• 页码：394-400
• 全文大小：1151 K

文摘

A series of biologically important substituted 3-fluorosalicylaldehyde derivatives (1a-h) with various primary amines were synthesized by using ionic liquid (1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide) as an efficient catalyst. A new series of Schiff base derivatives (1a-h) were synthesized and characterized by IR, NMR (¹H, ¹³C, ¹H-¹H COSY and HSQC), mass spectra and elemental analysis. Further crystal structure of compound 1a was evaluated by single crystal X-ray diffraction techniques. All the synthesized compounds were screened for in vitro antimicrobial activity against a panel of selected bacterial and fungal strains using Streptomycin and Amphotericin B as standards. Most of the synthesized compounds demonstrated moderate effects on both antibacterial and antifungal activities at minimum inhibitory concentrations (MIC¡¯s).