Theoretical modeling of actin-retrograde-flow passing clusters of confined T cell receptors

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• 作者：A. Ghasemi V. ^{ghasemi@mech.sharif.edu} ; B. Firoozabadi ; ^{firoozabadi@sharif.edu} ; M.S. Saidi ^{mssaidi@sharif.edu}
• 关键词：Actin retrograde flow ; T cell activation ; Myosin motor proteins ; Actin polymerization machinery ; Lamellipodium ; Lamellum
• 刊名：Mathematical Biosciences
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：283
• 期：Complete
• 页码：1-6
• 全文大小：1446 K
• 卷排序：283

文摘

An available experiment measuring actin retrograde flow over a region of confined receptors has been modeled theoretically. The model reproduces the measured velocity profile, which is an slowdown over the receptors, and a following speedup after that. The present study explains that the main factor in shaping the velocity pattern of the actin retrograde flow, is its driving force. The predicted driving force by the model, which is a pushing force by the upstream flow (provided by actin polymerization), and a pulling force from the downstream by Myosins corroborates the current understanding.