Autoinflammatory Skin Disorders: The Inflammasomme in Focus

详细信息    查看全文

• 作者：Prajwal Gurung¹ ; Thirumala-Devi Kanneganti¹ ; ^{thirumala-devi.kanneganti@stjude.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：inflammasome ; NLRP3 ; IL-1 ; CAPS ; FMF ; Ptpn6 ; Sharpin ; inflammatory ; autoimmune
• 刊名：Trends in Molecular Medicine
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：22
• 期：7
• 页码：545-564
• 全文大小：3470 K

文摘

Autoinflammatory skin disorders are a group of heterogeneous diseases that include diseases such as cryopyrin-associated periodic syndrome (CAPS) and familial Mediterranean fever (FMF). Therapeutic strategies targeting IL-1 cytokines have proved helpful in ameliorating some of these diseases. While inflammasomes are the major regulators of IL-1 cytokines, inflammasome-independent complexes can also process IL-1 cytokines. Herein, we focus on recent advances in our understanding of how IL-1 cytokines, stemming from inflammasome-dependent and -independent pathways are involved in the regulation of skin conditions. Importantly, we discuss several mouse models of skin inflammation generated to help elucidate the basic cellular and molecular effects and modulation of IL-1 in the skin. Such models offer perspectives on how these signaling pathways could be targeted to improve therapeutic approaches in the treatment of these rare and debilitating inflammatory skin disorders.