Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism

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• 作者：Abhishek Arya^a ; ^b ; ^{abhishekarya55@gmail.com} ; Hafsa Ahmad^a ; Sachin Tulsankar^b ; ^c ; Satish Agrawal^a ; ^b ; Naresh Mittapelly^a ; ^b ; Rajkumar Boda^a ; Rabi S. Bhatta^c ; Kalyan Mitra^d ; Anil K. Dwivedi^a ; ^{anilcdri@gmail.com}
• 关键词：Bicalutamide ; Hesperetin ; Antioxidant ; Reactive oxygen species ; Toxicity ; Prostate cancer
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：954-964
• 全文大小：1540 K
• 卷排序：71

文摘

Co-delivery by HSP in SNEDDS has overcome BCT induced tissue toxicities in rats. SNEDDS resulted in increase in oral bioavailability of BCT and HSP. ROS generation by HSP in PC-3 cells may be responsible for apoptosis. SNEDDS were absorbed by lymphatic pathway and clathrin-mediated endocytosis. Thermogravimetric analysis confirmed the polymorphic behavior of BCT.