Mitochondrial Diseases: Shortcuts to Therapies and Therapeutic Shortcuts

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• 作者：Michael P. Murphy¹ ; ^{mpm@mrc-mbu.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：6 October 2016
• 年：2016
• 卷：64
• 期：1
• 页码：5-6
• 全文大小：506 K

文摘

In this issue of Molecular Cell, Barrow et al. (2016) use two complementary approaches—one an assessment of a chemical library, and the other a genome-wide CRISPR screen—that both identify bromodomain-containing protein 4 (Brd4) as a therapeutic target for mtDNA diseases affecting complex I.