Non-covalent complexes of folic acid and oleic acid conjugated polyethylenimine: An efficient vehicle for antisense oligonucleotide delivery

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Non-covalent complexes of folic acid and oleic acid conjugated polyethylenimine: An efficient vehicle for antisense oligonucleotide delivery

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作者：Shuang Yang^a ; Xuewei Yang^a ; Yan Liu^a ; Bin Zheng^a ; Lingjun Meng^a ; Robert J. Lee^a ; ^b ; Jing Xie^⁎ ; ^{xiejing@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Lesheng Teng^a ; ^c ; ^{tenglesheng@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Oligonucleotide delivery ; Non-covalent ; Folic acid ; Polyethylenimine (PEI) ; Oleic acid ; Pathway
刊名：Colloids and Surfaces B: Biointerfaces
出版年：2015
出版时间：1 November 2015
年：2015
卷：135
期：Complete
页码：274-282
全文大小：2725 K

文摘

•: We synthesized a novel antisense oligonucleotide carrier PEI-OA for the delivery of LOR-2501.
•: PEI-OA/LOR-2501 complexes were further coated with folic acid and evaluated in tumor cells.
•: The levels of cellular uptake of FA/PEI-OA/LOR-2501 were much higher than PEI.
•: The levels of the uptake were not affected by the expression level of folate receptor.
•: We found that the complexes were mainly taken up by cells via the clathrin-mediated endocytosis.

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