Meta-analysis reveals a lack of association between MRP2 C-24T genetic polymorphism and the pharmacokinetics of mycophenolic acid in adult renal transplant recipients

详细信息    查看全文

• 作者：Kun Liu¹ ; Shuo Gu ; Xuzhong Liu ; Qing Sun ; Yunyan Wang ; Junsong Meng ; Zongyuan Xu ; ^{njmuwzj1990@sina.com}
• 关键词：Multidrug resistance protein 2 ; Mycophenolic acid ; Polymorphism ; Kidney transplantation
• 刊名：Meta Gene
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：11
• 期：Complete
• 页码：91-97
• 全文大小：437 K
• 卷排序：11

文摘

We firstly assessed the effect of the multidrug resistance protein 2 (MRP2) C-24T polymorphism on the pharmacokinetics (PKs) and safety of mycophenolic acid (MPA) in the literature. MRP2 C-24T polymorphism has no significant effect on the PKs of MPA in steady-state conditions or the safety of MPA in adult renal transplant recipients; MRP2 C-24T polymorphism is not associated with the safety of MPA in adult renal transplant recipients; Further large-scale, case-control studies with rigorous designs should be carried out to confirm these conclusions.