Probing the interactions of bromchlorbuterol-HCl and phenylethanolamine A with HSA by multi-spectroscopic and molecular docking technique

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Probing the interactions of bromchlorbuterol-HCl and phenylethanolamine A with HSA by multi-spectroscopic and molecular docking technique

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作者：Shuyun Bi ; ^{sy_bi@sina.com" class="auth_mail" title="E-mail the corresponding author} ; Tingting Zhao ; Huifeng Zhou ; Yu Wang ; Zhihong Li
关键词：Bromchlorbuterol-HCl (BCB) ; Phenylethanolamine A (PEA) ; Human serum albumin (HSA) ; Multi-spectroscopic technique ; Molecular docking
刊名：Journal of Chemical Thermodynamics
出版年：2016
出版时间：June 2016
年：2016
卷：97
期：Complete
页码：113-121
全文大小：1125 K

文摘

•: Molecular docking showed that BCB/PEA was bound at sub-domain IIA of HSA.
•: Fluorescence lifetimes indicated that the quenching was a static quenching.
•: CD spectra showed that BCB/PEA changed the conformation of HSA.
•: The competitive binding between site markers and BCB/PEA was studied.
•: The mutual influence on the two drugs binding HSA was studied.

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