Sclareol ameliorate lipopolysaccharide-induced acute lung injury through inhibition of MAPK and induction of HO-1 signaling

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• 作者：Yung-Hung Hsieh^a ; ^b ; ^c ; ^d ; Jeng-Shyan Deng^e ; ¹ ; Hsin-Pao Pan^b ; ^c ; Jung-Chun Liao^f ; Shyh-Shyun Huang^f ; ¹ ; ^{sshuang@mail.cmu.edu.tw} ; Guan-Jhong Huang^a ; ¹ ; ^{gjhuang@mail.cmu.edu.tw}
• 关键词：Acute lung injury ; Sclareol ; Anti-inflammation ; HO-1
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：44
• 期：Complete
• 页码：16-25
• 全文大小：1355 K
• 卷排序：44

文摘

Sclareol attenuated lipopolysaccharide (LPS)-induced acute lung injury in mice. Sclareol was associated with the modulation of iNOS and COX-2 signaling in lung injury tissue. Sclareol inhibited the degradation of NF-κB, IκBα, and the phosphorylation of MAPKs. Sclareol increased heme oxygenase-1 (HO-1) expressions in the lung tissue.