Iron catalysis for the synthesis of ligands: Exploring the products of hydrophosphination as ligands in cross-coupling

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• 作者：Maialen Espinal-Viguri^a ; Mary F. Mahon^a ; Simon N.G. Tyler^b ; Ruth L. Webster^a ; ^{r.l.webster@bath.ac.uk}
• 关键词：Iron ; Phosphine ligands ; C-C cross-coupling ; Amination
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：73
• 期：1
• 页码：64-69
• 全文大小：1139 K
• 卷排序：73

文摘

Catalytic hydrophosphination is a useful technique for the synthesis of phosphines, however, the phosphine products have been little exploited as ligands in catalysis. We have selected three phosphines prepared by iron catalyzed hydrophosphination and used them as ligands in a series of cross-coupling reactions: Heck, Suzuki-Miyaura and Buchwald-Hartwig. Rather than limit the chemistry to simple cross-coupling partners which are almost guaranteed to perform well in these transformations, industrially relevant substrates which are challenging from and electronic and/or steric perspective, along with substrates which contain several heteroatoms, were explored in order to gauge the true potential of these phosphine ligands.