Patient-derived xenograft models of squamous cell carcinoma of the uterine cervix

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Patient-derived xenograft models of squamous cell carcinoma of the uterine cervix

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作者：Einar K. Rofstad ; ^{einar.k.rofstad@rr-research.no" class="auth_mail" title="E-mail the corresponding author} ; Trude G. Simonsen ; Ruixia Huang ; Lise Mari K. Andersen ; Kanthi Galappathi ; Christine Ellingsen ; Catherine S. Wegner ; Anette Hauge ; Jon-Vidar Gaustad
关键词：Cervical carcinoma ; PDX models ; Metastasis ; Cancer stem cells ; Lymphangiogenesis
刊名：Cancer Letters
出版年：2016
出版时间：10 April 2016
年：2016
卷：373
期：2
页码：147-155
全文大小：4556 K

文摘

•: The PDX models mirror the biology and aggressiveness of the donor patients' tumors.
•: Metastasis of the PDXs is associated with the presence of intratumoral lymphatics.
•: Metastasis of the PDXs is related to high expression of angiogenesis-related genes.
•: Metastasis of the PDXs correlates with high expression of stem cell-related genes.

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