Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal

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• 作者：William C. Adams¹ ; ⁶ ; Yen-Hua Chen¹ ; ⁶ ; Radomir Kratchmarov¹ ; ⁶ ; Bonnie Yen¹ ; Simone A. Nish¹ ; Wen-Hsuan W. Lin¹ ; Nyanza J. Rothman¹ ; Larry L. Luchsinger² ; Ulf Klein³ ; Meinrad Busslinger⁴ ; Jeffrey C. Rathmell⁵ ; Hans-Willem Snoeck² ; Steven L. Reiner¹ ; ⁷ ; ^{sr2978@cumc.columbia.edu}
• 关键词：asymmetric cell division ; TCF1 ; Pax5 ; Warburg effect ; stem cell ; self-renewal
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：17
• 期：12
• 页码：3142-3152
• 全文大小：5498 K
• 卷排序：17

文摘

Activated lymphocytes yield sibling cells with unequal clearance of aged mitochondria Stasis of progenitor mitochondria marks T cells destined for differentiation in vivo Mitochondrial stasis is linked to anabolism, inhibited autophagy, and glycolysis Key transcription factors intertwine the control of metabolic program and cell fate